Two unusual presentations of vitamin B12 Deficiency.
نویسندگان
چکیده
Vitamin B12, a water-soluble vitamin is important in DNA synthesis. Inadequate intake of animal foods and pernicious anaemia (loss intrinsic factor due to autoimmune atrophic gastritis) are known be the most common causes severe deficiency worldwide (1).
 Although patients with have only mild haematological findings, very few presents present symptomatic pancytopenia, (haemaglobin
منابع مشابه
Recurrent seizures: an unusual manifestation of vitamin B12 deficiency.
The present report highlights an unusual presentation of vitamin B12 deficiency--recurrent seizures in a 26-year-old man. His symptoms responded to parenteral vitamin B12 therapy. The relevant literature is reviewed.
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Functional vitamin B12 deficiency is a syndrome where a wide variety of symptoms in the presence of “normal” serum levels of the vitamin respond to vitamin B12 therapy. A series of patients with functional vitamin B12 deficiency are described whose presenting features were drenching night sweats and fatigue. Reliance on serum vitamin B12 levels as a diagnostic test would have obscured the cause...
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Patients with subacute combined degeneration who smoked had significantly lowered plasma thiocyanate levels than control smokers, but plasma thiocyanate levels in non-smoking patients with neurological disease due to vitamin B1, deficiency were not significantly different from control values. The results provide no support for the hypothesis that chronic cyanide intoxication is responsible for ...
متن کاملVitamin B12 deficiency.
Haematology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK Correspondence to: A Hunt [email protected] Cite this as: BMJ 2014;349:g5226 doi: 10.1136/bmj.g5226 Vitamin B12 is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious c...
متن کاملDeficiency of vitamin B12-binding alpha globulin in two brothers.
E NDOGENOUS VITAMIN B12 circulates bound to an alpha-i glycoprotein.”2 Added vitamin binds primarily to a globulin with beta mobility electrophoretically, which may serve mainly a temporary transport function.3’4 This beta globulin readily gives up its vitamin B12 to cells, while the alpha globulin seems to serve as a circulating storage depot.3’5’6 With the exception of some conditions involvi...
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ژورنال
عنوان ژورنال: Journal Of The Postgraduate Institute of Medicine
سال: 2023
ISSN: ['2362-0323', '2362-0315']
DOI: https://doi.org/10.4038/jpgim.8379